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There were similar rates of mild adverse events (e.g., nausea, restlessness, insomnia, irritability) across groups in trials of cytisine based on our initial overview.22 However, an updated Cochrane review on cytisine42 suggested there may be a small increase in adverse events, which could constitute a small harm (4 RCTs, n = 4052

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Early signs include redness, swelling, and tenderness, which can worsen with continued smoking

And occasionally the Virginia flake like Dark Star, and Blackwoods Flake, etc

Its painful to me

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