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While humans continuously swallow saliva, which permits oral bacteria to pass through the digestive tract, the introduction of smoking appeared to allow these microbes to establish residence in the gut mucosa

doi:10.1016/j.tree.2021.10.001 Koroleva, E., Mqulwa, A

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According to the Slovak Minister of the Interior, the tunnel was a technically advanced structure which may also have been used to traffic people ( European Parliament 2012 )

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However, researchers are actively exploring whether changes in the vaginal microbiome, including dominance by Gardnerella , might play a role in how the body responds to HPV