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Three of the patients underwent bath PUVA (immersion for 15min in 2.4mg/L methoxsalen at 3742C) and the other 2 patients received oral PUVA (0.6mg/kg Oxsoralen 2h before exposure to UVA)

However, differences were found in the severity between groups based on exposure to cigarette smoke

Comprehensive genomic analyses have revealed a distinct tobacco-related mutational signature in liver tumors of smokers, characterized by cytosine-to-adenine base substitutions, dinucleotide alterations, and guanine adduct formation, patterns resembling those observed in lung and head-and-neck cancers [38,39,40]

Serge Gainsbourg in his favoured pose with a cigarette

The good news: smoker lips are reversible with the right approach

The best way to protect your teeth and gums is to quit smoking