local anti tobacco activists are calling for Activists Hold Anti-Tobacco Rally on World No Tobacco Peru Squeezes Big Tobacco -

According to the CDC, smoking causes an estimated 443,000 premature deaths and costs the United States nearly $200 billion dollars (divided roughly evenly between lost labor costs and health care expenditures) per year

Smoking cessation: a report of the Surgeon General (Department of Health and Human Services, 2020)

Substance Use Disorder Treatment Health conditions resulting from or worsened by substance use will likely not improve without reducing substance use

3=bilateral eye

Updating dopamine reward signals

They are the perfect storm, occupying the space at the highest level on all three dimensions (highest on all axes, Figure 2)