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4 Discussion Our study offers a novel perspective on the complex relationship between smoking history and the incidence of delirium, By isolating former smokers as a distinct group, we aimed to elucidate their specific risk of delirium, a departure from previous studies that often combined former smokers with either current or non-smokers ( This insight into the durable influence of smoking on the immune system provides a possible explanation for the increased susceptibility of former smokers to delirium in the ICU setting, as neuroinflammation is a potential mechanism of POD ( In contrast, our study did not demonstrate a similar difference in delirium incidence between active smokers and non-smokers

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