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The computed energy barrier for Cu(II)-catalyzed methionine oxidation is 14.3 kcal/mol significantly lower than for Zn (19.6 kcal/mol) or Fe (16.9 kcal/mol), making copper the most efficient catalyst among common metal ions

In rat hindlimb ischemia models, this mechanism accelerated blood flow recovery and increased vessel density in oxygen-deprived tissues

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