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Of interest, the cryo-EM map suggests that the NTD is not in contact with the 7TM region, although based on our refined structure we raise the possibility of Gln213 of ECL1 interacting with Arg40 located in the 1-helix of the extracellular domain (Fig

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If symptoms persist beyond one to two weeks or worsenespecially with hearing lossit may indicate ongoing damage or central sensitization, increasing the risk of chronic tinnitus