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6 Semaglutide produced significantly greater weight loss (an 1112 kg difference versus placebo) and larger improvements in pain (Western Ontario and McMaster Universities Arthritis Index [WOMAC] score: 41.7 versus 27.5)

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On the other hand, T2DM is often associated with increased body mass index (BMI), and other studies have suggested that levels of plasma DPP-4 activity actually correlate better with clinical parameters of obesity rather than of T2DM and glucose per se

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