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Long-Term Dependence As use continues, tolerance and withdrawal symptoms become more pronounced

doi:10.1016/S2221-1691(12)60220-2
Influence of the Cyp2d6*4 polymorphism on dose, switching and discontinuation of antidepressants

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76 Smoking has been associated with the release of the 70-kDa heat-shock protein in the lung and by human monocytes and lung fibroblasts in vitro
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