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Heavy use may be leading to some of the following depressive symptoms: 2,5,6 Loss of motivation and drive Feeling more drained and tired Feeling foggy or unable to focus Feeling sad, somber, bored, or down Moving slower, feeling sluggish Wanting to sleep more often or for longer Trouble starting or completing basic tasks Feeling apathetic, numb, or disinterested Different strains of cannabis may produce slightly different highs

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doi: 10.3389/fpsyt.2022.1114432 Received 02 December 2022 Accepted 20 December 2022 Published 09 January 2023 Volume 13 - 2022 Edited by Domenico De Berardis, Department of Mental Health, ASL 4, Italy Reviewed by Francesco Monaco, Azienda Sanitaria Locale Salerno, Italy

P-AT was responsible for reviewing and commenting on the manuscript drafts