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10.3389/fimmu.2021.749291 3 AmirshahrokhiK.NiapourA

Elevated levels of CXCL2, a macrophage inflammatory protein, may explain the persistent inflammatory response and airway smooth muscle migration observed in our study

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This corresponds to the ability to detect a difference of at least 2 cigarettes per day (SD = 3) or at least a 13% difference in percent days smoke-free (SD = 20%), consistent with effect size estimates from our work and other studies [19, 33]

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And no, it wont be a CVT onlysome outlets wrongly reported this a few months back