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It is not a comparison of the overall disease burden of smoking versus drinking

VG, vegetable glycerin
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The requirement to place a smoking area under negative pressure has been around since 1989

Using the entire hemisphere as the seed region-of-interest, Viswanath and colleagues showed increased inter-hemispheric FC in sated cigarette smokers as compared to controls, which was positively correlated with the number of cigarettes smoked per day 9
