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The harmful chemicals in cigarette smoke can damage the DNA in skin cells, impairing their ability to function properly and increasing the likelihood of mutations that can lead to cancerous growths

Tobacco smoking in Sub-Saharan Africa: A systematic review and meta-analysis

For the purposes of this report, the key question is the one posed by a recent National Cancer Institute monograph: Is achieving abstinence harder, and do changes to interventions need to be made

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Moreover, the quantity smoked, as well as the presence of nicotine dependence, is correlated with the age at initiation