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Dimensions: 3407 x 5120 px | 28.8 x 43.3 cm | 11.4 x 17.1 inches | 300dpi Date taken: 4 September 2004 More information: A glass ashtray full of old cigarettes and matches no smoking chain smoking

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If e-cigarette product use is suspected as a possible cause for a patients lung disease, a detailed history of the substances used, the sources, and the devices used should be obtained, as outlined in the Health Alert Network (HAN), and efforts should be made to determine if any remaining product, devices, and liquids are available for testing

The carcinogens cause direct damage to the DNA of bladder cells by forming DNA adducts, which disrupt essential genes responsible for cell repair and regulation, such as TP53

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