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Elevated HbA1c and insulin resistance are positively correlated in a dose-dependent manner and can be determined by the euglycemic clamp technique

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This was reported in a study showing that nicotine-containing and nicotine-free vaping liquids both had the same negative impact

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However, macrophages treated with nicotine exhibited upregulated expression of CD36, possibly via the ROS/PKC/PPAR signaling pathway [128]