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Code availability ExWAS analyses and PheWAS analyses was performed via the R package SAIGE GENE+ which was available on Burden heritability regression analysis was performed via the R package BHR (v.0.1.0, Annotation of significant variants was conducted with SnpEff ( Gene ontology enrichment analysis was conducted using g:Profiler ( and tissue enrichment analysis was performed via the R package TissueEnrich (v.1.16.0, The scRNA-seq data were analyzed and visualized using the R package Seurat using the R package Seurat (v.4.3.0, Gene-Scout was available through the website: References Griswold, M

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