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It has also been shown that cbNPs accumulate in antigen-presenting dendritic cells derived from emphysematous lung tissue of smokers [73] and that cigarette smoke triggers the NLRP3 inflammasome [63], which is again consistent with the observation that IL-1 levels are elevated in smokers lungs [19]

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We found a moderate correlation of CPD and urinary cotinine, as Pearsons r was 0.4 for both, men and women (Table 2)