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Nicotine or smoking is an environmental variable that increases the incidence of CD and doubles that risk

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doi: 10.1016/s0072-968x(77)80001-6

Appeal: The brand appeals to markets where subtlety and inherited tradition carry more weight than bold, modern imagery

For some patients, especially those with severe esophagitis, Barretts esophagus, or certain complications, long-term PPIs are appropriate and protective