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Description
Tissue Int
Once cancer begins infecting other regions of the body, it becomes very difficult to completely destroy all of the cancer cells
More recently, TP53 missense mutations were identified in BCC samples, including hotspot positions p.H179Y, p.S241F, p.G245N, and p.R280K, clustering in p53 DBD [100]
As previously referred, inflammatory pathways can also be activated by UVR-induced ROS or indirectly by DNA or mitochondrial damage, where both keratinocytes and fibroblasts contribute to the inflammatory condition and extracellular matrix degradation
doi: 10.1371/journal.pone.0073656
The phosphatidylinositol 3-KinaseAKT pathway in human cancer
