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Hence, one might postulate that given the potentially large effect size of the aforementioned factors associated with both smoking status and IBD, that the magnitude of any direct mechanistic or toxic effect of smoking constituents on the intestinal milieu or treatment(s) might in fact be dwarfed by these cofactors, as represented in Fig

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[1] Partly due to favorable taxation compared to filtered "white" cigarettes, [2] kreteks are by far the most widely smoked form of cigarettes in Indonesia, where they are preferred by about 90% of smokers