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tobacco cost calculator Smoking Smoking and Health Care Costs
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This includes many LMIC, where it is likely that e-cigarettes are not yet available or are only used by a minority
The elephant in the room is of course how irritating it is to get

With some excise categories it is easier: the average cost of a mile driven by an average car on an average road, to cite one example

FDA classifies prescription formulations of nicotine as pregnancy category D, indicating that there is evidence of risk to the human fetus