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While smoking can suppress appetite and increase metabolism, it is not a healthy or sustainable way to lose weight

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Once absorbed, it enters the bloodstream and is distributed, at various concentrations, to all tissues and organs, including the brain

(Adejumo, Adeyinka Charles et al.) Mechanistic/physiology data: Human studies in healthy volunteers with dronabinol (a cannabinoid medicine) demonstrate reduced post-prandial colonic tone and motility, influenced by endocannabinoid system genetics (e.g., FAAH, CNR1 variants)