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Endothelial injury generated directly by intracellular viral replication and by ACE2 downregulation, exposing cells to angiotensin II in the absence of the modulator effects of angiotensin 17 (270, 271), and vascular chronic inflammation promoting the development of tissue macrophages overloaded by cholesterol (foam cells), both increase the possibility of acquiring a severe COVID-19 infection (209, 258, 259, 272, 273)

and Moorthy B., Role of Cytochrome P450s in the Generation and Metabolism of Reactive Oxygen Species, Current Opinion in Toxicology 7 (2018): 4451

doi: 10.1097/00005082-200601000-00004

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Samples were then precipitated with 1 mL absolute MeOH at 40 C for 2 h, centrifuged (16,000 g at 0 C), and the obtained supernatants was evaporated and the residue was resuspended and sonicated in 100 L 50 mM HEPES buffer (pH 7.4)

doi: 10.1007/s00284-005-0020-3 43 AagaardKMaJAntonyKMGanuRPetrosinoJVersalovicJ