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Fourth, participants whose survey completion times fell below an empirically established threshold of 18 mindetermined through pilot testingwere excluded ( n = 683)

An additional literature search was conducted to ensure the inclusion of the most up-to-date evidence, resulting in the selection of 16 RCTs.58, 108, 117, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198 The results showed that combination NRT group showed significantly increased smoking cessation success rates at six months or longer compared to the NRT monotherapy group (RR, 1.26

In addition, exhaled nitric oxide measurements evidenced an increase from day 1 to 5 mainly in the EC use and tobacco cessation groups (52)

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E-cigarettes were the most popular tobacco product among the children and adolescents

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