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Physical health is also affected by nicotine use

When the cigarette is burned at high temperatures, these chemicals are converted into additional toxic compounds that significantly increase the health risks
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Eisner MD, Klein J, Hammond SK, et al

Indeed, the average ratio of NNN to NNK, which varies significantly by tobacco plant type, is 1.2 (0.3) in the tobacco filler of the low-TSNA NAS varieties, which is typical of cigarettes made with Virginia-type bright tobacco.40 This ratio in other brands analyzed here is 3.2 (0.8), which is commonly observed in the American-blended cigarettes
