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[28] In the early 16th century, the Spanish Casa de Contratacin (House of Trade) established and held a trade monopoly in the first manufacturing industries of snuff, in the city of Seville, which became Europe's first manufacturing and development centre for snuff

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Price mix is used to explain the value component of the sales as the Group sells each unit for a value (price) but may also achieve a movement in revenue due to the relative proportions of higher value volume sold compared to lower value volume sold (mix)