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The agency in October ended the tirzepatide injection shortage prematurely based on representations from drugmakers and incomplete data on demand for the compounded versions of the drug, Scott Brunner, CEO of Alliance for Pharmacy Compounding, another compounding industry group, said in a statement to ABC News

[DOI] [PubMed] [Google Scholar] 326.Burhol P.G., Waldum H.L., Jorde R., Lygren I

Patients with type 2 diabetes have an impaired insulin response to GLP-1 that is believed to be secondary to reduced post-prandial GLP-1 secretion [60]

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While effective for weight loss, these compounds must be carefully titrated to minimize adverse events

Compared to GIP, which has normal secretion but poor response in patients with T2D, GLP-1, which has low secretion but preserved response, is an important target in the development of antidiabetic drugs