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Transitions from desensitized to resting/closed state require substantial conformational changes in LBD and the LBD-TM linkers In the gating cycle, post-desensitization, receptor needs to recover to a resting state, where the LBDs couple as 2-dimers for the next cycle of activation

Additionally, polystyrene MP reduces lipid digestion by forming heteroaggregates with lipids and adsorbing lipase [273]

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Kong Y, Yang H, Nie R et al (2025) Obesity: pathophysiology and therapeutic interventions