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Description
Among the 2,120 patients with CD whose data were complete, the HRs for ever smoking, previous smoking, and current smoking were 1.2719 (95% CI: 1.16361.3903, p = 1.19e-7), 1.2655 (95% CI: 1.15541.3869, p = 3.98e-7) and 1.3707 (95% CI: 1.21141.5509, p = 5.62e-07), respectively, greater than those of never smokers

Quitting enhances the bodys response to these interventions

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In addition to the criteria established within organ systems, family history (1st-degree relative with Marfan syndrome) and genetic history (presence of the FBN1 mutation known to cause Marfan syndrome) are considered major criteria
