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There is much controversy around the potential for e-cigarettes to help people quit smoking, even though it is estimated that the devices are up to 95% less harmful than cigarette smoking

[37] There are many e-liquids manufacturers in the US and worldwide, [38] and more than 15,500 flavors existed in 2018

These smokers, who remain something of a medical mystery, have smoked up to a pack a week for years, or even decades, without becoming dependent on nicotine

Published Online First: 06 February 2019

However, experts have performed most of the research into nicotine and headaches in the context of tobacco smoking

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