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A significant positive correlation of 4-aminobiphenyl, a hepatic carcinogen in CS, with HCC risk has been shown in humans (Wang et al., 1998
Inflammation and tumor progression: signaling pathways and targeted intervention
This finding may partly explain why CS-induced deleterious phenotypes can be transmitted to the progeny of smokers
Zhang J, Sun WQ, Kong XMD, Zhang YH, Yang HJ, Ren C, et al
& Chene, P
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