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Probably the most striking message from the genetic literature is that despite the very robust heritability of schizophrenia, the very small genetic effects in many risk loci, will continue to require larger and larger samples (i.e., tens or hundreds of thousands), to be able to account for a large proportion of variance in the risk for the illness

Mohandas E, Rajmohan V, Raghunath B (2009) Neurobiology of Alzheimer's disease

While such inhibition causes modest or undetectable increases in H 2 O 2 contents, it triggers a marked perturbation of both the glutathione pool size and redox state (Smith et al., 1984

For subfamily AhpC-PRX1, we searched for the motifs GGLG and YF that encode sensitivity to hyperoxidation, as well as a and b motifs that contribute to determining the degree of PRX sensitivity to hyperoxidation 56,57,58,64

British Journal of Pharmacology, 130, 851856

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