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Unlike medications that target only one pathway, tirzepatide injections work through two hormonal systems, reducing appetite, enhancing insulin sensitivity, and potentially increasing calorie burning

Weight loss changes the body distribution of thyroid medication and may require dosing adjustments

Kawamata, M., Suzuki, H., Kimura, R

Substitution Threat 3.3.1.4
Brown & Brown

Moreover, in diabetes, mechanisms that normally counteract increased oxidative stress, such as upregulation of HO-1, are impaired, leading to loss of ICC and subsequent delay in gastric emptying
