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Nicotine can acutely increase energy expenditure, but prolonged use may alter appetite regulation, cortisol patterns, and insulin sensitivity

Regional Review Continued Asia-Pacific, Middle East and Africa (APMEA): - New Category revenue declined 4.5%, but was up 2.6% at constant rates of exchange, driven by the growth of Vapour in South Africa - Combustibles performance impacted by a translational foreign exchange headwind with constant rate growth led by robust pricing - Combustibles value share down 60 bps with volume share down 20 bps Volume/Revenue Please see page 53 for a full reconciliation to constant currency and organic metrics, including prior year data