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Nicotine is a drug that is naturally present in the tobacco plant and is primarily responsible for a person's addiction to tobacco products, including cigarettes
This innovative approach allowed us to compare the effects of tested products in realistic conditions, reflecting observations from human studies showing that people who use alternative tobacco products have comparable exposure to nicotine to people who smoke CC [42,43,44,45]

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The two suggested phenotypes in this data are not entirely distinct, nor would they be expected to be since TTFC and daily cigarette frequency are just two behavioral measures of nicotine dependence, which is characterized by a physiological desire and craving for nicotine, the perceived good feelings it generates, and unpleasant withdrawal symptoms

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