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Given that reduced survival was found to be greatest for smokers in the group with most indicators of immune cells, the researchers think that smoking could directly affect how smokers' bodies deal with the melanoma cancer cells

doi:10.1038/ajg.2014.71

Ive noticed this in my own nicotine useon days when I used the gum while already feeling clearheaded, I sometimes felt jittery, not sharper

Thats according to research published in Alcoholism: Clinical & Experimental Research in 2014