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Of these, 5,462 were current regular e-cig users (had used e-cigs on at least 30 days, including the past 7 days)

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Excessive consumption of sugar can also lead to an imbalance in the dopamine response, resulting in increased cravings, the need for more sugar, and the potential for addiction [4]

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The possible roles of TNP1, revealed by in vitro investigations, include relaxation of the DNA in nucleosome core particles, decreasing the melting temperature of DNA, and stimulation of the DNA-relaxing activity of topoisomerase I [73, 75, 76, 77, 78]