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However, by 1954, industry strategists deemed physician images in advertisements no longer credible in the face of growing public concern about the health evidence implicating cigarettes

These countries, including Australia, Ireland and Canada, require all tobacco products to be sold in plain packaging (drab dark brown with matt finish)

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Each operator has a smoking ban and fine in their terms and conditions to protect themselves from this behavior

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For example, nicotine can affect dendrite cellular function [154][155], and may cause cytokine changes and produce growth factor involved in Kaposis sarcoma development [156]