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With the help of West Virginia Senator Jennings Randolph, Congress amended the law in 1974 to exclude signs on farm structures or natural surfaces, or, as in this case, of historic or artistic significance

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The efficacy and safety of varenicline was evaluated in a randomized, double-blind, placebo-controlled study of 312 patients aged 12 to 19 years, who smoked an average of at least 5 cigarettes per day during the 30 days prior to recruitment, had a score of at least 4 on the Fagerstrom Test for Nicotine Dependence scale, and at least one previous failed quit attempt

By February 2008, Ploom raised $900,000 in venture funding, putting its valuation at roughly $3 million, according to PitchBook

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