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Moreover, in vitro studies have demonstrated that RIF induces various CYP enzymes, including CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and CYP3A5 (Rae et al., 2001

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Obtaining and approving progress reports throughout the duration of its agreements, including providing written justification to support assessments of contractors progress, and taking steps to remediate any problems with contractor performance, such as withholding payment from contractors that do not submit timely and accurate agreement deliverables

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