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Early signs of lung damage, such as parenchymal micronodules, ground-glass attenuation and emphysematous changes, have been described in asymptomatic smokers with and without spirometric abnormalities 40,41,42

On the other hand, the late-phase response, including the synthesis of LTC 4 and TNF-, as well as the mRNA expression of TNF- and IL-1 were significantly inhibited by NT treatment

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