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In the nucleus, AIF orchestrates cleavage of genomic DNA into large fragments resulting in cell death

Taken together, although it does not have direct mechanisms that can explain HIV-induced HCC initiation and progression as the main hepatic supervisors of hepatocyte destructiveregenerative process, CD4 + T-cell and Kupffer cell exhaustion might contribute to abnormal hepatocyte proliferation, especially in hepatocytes with hepatitis virus infections

Grajeda-Iglesias C, Rom O, Hamoud S, Volkova N, Hayek T, Abu-Saleh N, Aviram M (2018) Leucine supplementation attenuates macrophage foam-cell formation: Studies in humans, mice, and cultured macrophages

doi: 10.1016/j.ceb.2009.12.001

Mol Gen Genet

doi: 10.1016/j.bbcan.2020.188393 87 DaviesLSpillerDWhiteMRGriersonIParaoanL