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The rate was 1.5 times higher among ex-smokers who stopped during the last decade than those who never smoked

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Nicotine and chemicals in cigarette smoke can cause the blood vessels in the ears to constrict or become damaged, interfere with neurotransmitters in the auditory nerve, trigger the release of free radicals (which can damage DNA causing disease), and cause tinnitus

Assisted by suitable regulatory frameworks that advocate their adoption, they have the potential to help correct the many enduring misconceptions about combustible tobacco and nicotine and make a meaningful contribution to tobacco harm reduction for the worlds one billion-plus adult smokers

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2 This article focuses on nicotine as a determinant of addiction to tobacco and the pharmacologic effects of nicotine that sustain cigarette smoking