glp 1 receptor agonists for type 2 diabetes GLP-1R and GLP-1 Receptor Agonists and Research

Acting as incretin mimetics, they enhance glucose-dependent insulin secretion, suppress glucagon release, delay gastric emptying, and promote satiety, addressing several core abnormalities in T2DM pathophysiology (Ahmann et al., 2015)

Philips EM, Santos S, Trasande L, Aurrekoetxea JJ, Barros H, von Berg A et al

Medications like Wegovy and Zepbound can cost hundreds or even thousands of dollars per month

2015;10(6):e0126769

The CCI was modified to exclude kidney disease and late-diabetic complications, as these covariates were separately adjusted for in the statistical analyses

This mechanistic diversity suggests that GLP-1RAs could be repurposed to target complex, multifactorial disorders like schizophrenia, bipolar disorder, and bulimia nervosa, where current treatment options are limited or suboptimal