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The inclusion criteria and results of the systematic review approach are reported in accordance with PRISMA guidelines 31

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More research is needed to confirm these effects in humans and determine dosage levels, but these findings show promise, said Philip Lazarus, WSU professor of pharmaceutical sciences

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This crucial dividing line was drawn by the 2018 U.S

For example, "Sod off, you tosser!" said in an angry tone would be considered as an insult, but "Sod off, you tosser!" said in a teasing tone of voice would be considered poking fun