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Congress created a special rule for exposure modification orders, allowing FDA to authorize such claims where long-term epidemiological evidence may not yet be available, but the available evidence supports that the product is reasonably likely to reduce morbidity or mortality, substantially reduce exposure to harmful substances, and not mislead consumers into believing that the product has been shown to reduce disease risk unless that has been demonstrated

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A comprehensive study published in JAMA Network Open, which analyzed over 3.9 million participants, found no significant link between ADHD medications and cardiovascular disease in most groups