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Becoming dependent on the psychological effects and the habit and comfort of smoking is the hardest thing to break from
Pharmacol 74 , 111 (2016)

Intensive research followed, and researchers soon learned that the nicotine receptors were in fact designed to bind the neurotransmitter acetylcholine, and it was just an accident of nature that nicotine, an obscure chemical from a tobacco plant, was also able to bind to them

Wilbert Robicsek (1978), p
But do you check the air
February 27, 1904