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One of the big issues is that nicotine intake increases the presence of the receptors that nicotine binds to, which goes some way to explaining why it is harder to give up smoking if you have been smoking for a while

Temporary Effects of Smoking and Nicotine on Blood Pressure Unfortunately, most studies have focused on the effects of smoking on blood pressure rather than on nicotine alone (although, as I explain at the end of this post, more studies are on their way)

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