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People with diabetes who also smoke are more likely to: experience kidney and heart disease have poor circulation leading to infections, ulcers, blood clots, or amputations develop eye diseases, such as retinopathy, that can lead to vision loss experience nerve damage that leads to pain, tingling, and mobility impairments Many of the combined health effects of smoking and diabetes make it more difficult to make healthful lifestyle choices

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However, the up-regulations of GSH, L-Glutamic acid, pyroglutamylglycine, GCL and GS caused by AZI were also abolished by sh-Nrf2 transfection in CSE-incubated HBECs (Fig

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