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113 In addition to increased gene and protein expression of MMP-2/9, a recent study demonstrated that aortic segments harvested from mice chronically exposed to nicotine exhibited increased elastolytic activity accompanied by elastin thinning and fragmentation, indicative of increased susceptibility to aortic aneurysm

wherefore, whenever the ends of government are perverted and public liberty manifestly endangered, and all other means of redress are ineffectual, the people may, and of right ought, to reform the old or establish a new government

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